Physiological Signal Intelligence · API Infrastructure

Detect subclinical deviations before costly clinical escalation.

PhysioSim Systems is an API infrastructure layer that learns each individual's physiological baseline from longitudinal, multi-signal data — and surfaces persistent, meaningful deviations.

PhysioSim does not diagnose and does not make clinical decisions. It supports earlier clinical awareness. All outputs require human review before any action is taken.

// Signal-to-action workflow
Data
API
Risk
Review
Action
10+
Signal types: HR, SpO₂, RR, weight, BP, ECG, activity
Comprehensive monitoring
3
Clinical validators
EM, NICU, pre-hospital
$108B
Annual US HF costs
AHA, 2023
$50B+
Global trial monitoring spend
Grand View, 2024
The Problem

Chronic care management drives over 50% of healthcare spending — largely preventable readmissions. Clinicians lack tools to interpret multi-signal trends in real time.

The Solution

PhysioSim learns each person's physiological baseline from longitudinal data — and detects persistent deviation before it becomes a clinical crisis.

// The problem

Physiological deterioration is gradual. Detection is always too late.

Static Thresholds Fail

Population-based alert rules don't account for individual baselines. They create false alarms or miss early drift entirely.

Signal Overload

EHRs, devices, wearables — care teams have data streams but lack tools to interpret multi-signal trends in real time.

Alert Fatigue

Noisy monitoring queues erode clinical trust. Real signals get buried under false positives.

No Intelligence Layer

No API product exists that learns per-individual baselines at scale and routes actionable alerts into existing workflows.

// Our solution

Individualized baselines. Persistent deviation detection. Workflow-native delivery.

Individualized Baseline Modeling

PhysioSim builds a personalized model per patient — no population averages, no one-size-fits-all thresholds.

Multi-Signal Deviation Detection

We detect persistent deviations across weight, HR, activity, symptoms, labs — frequency-domain and waveform features when available.

Risk Stratification with Rationale

Low / medium / high risk output with concise, explainable reasoning — care coordinators can act without physician review for every case.

Workflow-Native Delivery

Outputs route into existing nurse queues, care coordinator tools, and clinical systems. No new dashboard required.

⚠ PhysioSim does not diagnose medical conditions or make clinical decisions. It supports earlier clinical awareness. All outputs require human review before action.

// Use cases

One engine. Multiple applications.

Same individualized baseline intelligence across chronic care monitoring and clinical trial safety.

Chronic Care Monitoring

Earlier intervention.
Fewer admissions.

For RPM programs, payers, ACOs, and health systems managing high-risk populations.

Heart failure — primary use case
Medicare Advantage, ACOs, VA
Nurse-first routing into existing workflows
Clinical Trial Safety

Earlier safety signals.
Smarter monitoring.

For pharma sponsors and CROs running decentralized or hybrid trials.

Decentralized & hybrid trials
Individualized adverse event detection
FDA-aligned remote surveillance
// How it works

Five steps from raw data to clinical action.

01

Ingest

Patient data flows in from existing sources — EHRs, remote monitoring tools, wearables — via standard interfaces.

02

Model the Individual Baseline

PhysioSim builds a personalized baseline for each patient. Each signal is characterized relative to that individual's normal range.

03

Detect Persistent Deviation

We flag sustained, multi-signal deviation that exceeds the patient's historical variance — emphasizing persistence over transient noise.

04

Route to Nurse / Care Coordinator First

Alerts with concise, explainable rationale are delivered to the first-line care team — not physicians by default.

05

Review, Contact, Escalate as Warranted

The care team reviews the alert, contacts the patient, and escalates to a physician only when clinically warranted.

// Sample demo

See the API work — with sample data only.

This demonstration uses illustrative, fictional patient data. No real patient information is shown.

POST api.physiosim.io/v1/patients/analyze
// PhysioSim Systems API — Sample Data Only
 
POST /v1/patients/analyze
 
{
  "patient_id": "SAMPLE-A",
  "program": "heart_failure_rpm",
  "baseline_days": 60,
  "signals": {
    "weight_kg": 85.2,
    "resting_hr_bpm": 92,
    "daily_steps": 1640
  }
}
 
// Ready — press Run to simulate →
⚠ Sample data only. This is a simulated demonstration for illustrative purposes.
ID: SAMPLE-A · HF RPM Program
Sample Patient A — Illustrative
● Awaiting...
Weight
85.2 kg
Baseline: 83.1 kg
Resting HR
92 bpm
Baseline: 72 bpm
Daily Steps
1,640
Baseline: 3,900
Symptoms
Reported
Flag: dyspnea
⚠ Sample Output: Deterioration Risk — HIGH
Sustained upward shift in weight (+2.1 kg over 6 days) with concurrent resting HR elevation (+9 bpm over 5 days) and activity decline. Symptom check-in: increased dyspnea reported 2 of last 3 days. Recommend same-day nurse contact.
// Clinical & trial workflow

Built to fit existing workflows — not replace them.

1

Human-First Routing

Alerts route to nurses, care coordinators, or trial safety monitors as first-line reviewers. Physicians receive escalations only when warranted.

2

Human-in-the-Loop

Every alert requires human review before any action. PhysioSim surfaces risk and rationale; clinicians own the decision.

3

Noise Reduction by Design

Transient anomalies are de-emphasized. Only persistent, multi-signal deviation triggers alerts — reducing queue volume and restoring trust.

// For investors & partners

A large, measurable problem.
A clear infrastructure solution.

Why now

  • Remote monitoring adoption accelerated post-pandemic — intelligent analysis layers don't exist yet
  • Decentralized Clinical Trials (DCTs) growing rapidly — FDA guidance requires remote monitoring
  • Individualized, explainable AI now feasible at scale with wearable data
  • Heart failure alone drives $26B+ in preventable costs annually

Target buyers

  • Insurance payers & government programs seeking readmission reduction
  • Health systems operating remote patient monitoring programs
  • ACOs with value-based care incentives
  • Pharma sponsors & CROs running decentralized trials
// Market sizing (published sources)
$8.3B
Global Remote Patient Monitoring market
Grand View Research, 2024
$50B+
Global clinical trial monitoring spend annually
Grand View Research, 2024
$26B+
Annual cost of preventable HF readmissions
AHRQ / ESC literature
// FAQ — for healthcare teams

Common questions, direct answers.

// Security & privacy

Pilot-ready. Conservative by default.

🔒

Data Minimization

Only fields required for pilot use cases are ingested. No unnecessary data collection.

🛡

Encryption

Data encrypted in transit. Encryption at rest where stored. De-identified workflows supported.

👁

Access Controls

Role-based access to pilot artifacts. Access logs maintained for all interactions.

Clinical Safety

Decision support only. Care team review required before any patient action.

📋

HIPAA-Minded by Design

Pre-commercial. Built with HIPAA alignment as design principle — data minimization, access controls, encryption.

Regulatory Positioning

Risk detection / decision support (not diagnosis). Requirements assessed per deployment.

// From the founder
"PhysioSim is being built for real care delivery environments — high signal density, limited staffing, and the need for actionable, explainable alerts that reduce preventable admissions."
— Phoebe Garcia, Founder & CEO

Request Access to PhysioSim Pilot

PhysioSim is currently in pre-commercial pilot stage. Access is by approved partner arrangement only. We are working with select healthcare systems, payers, and clinical research organizations.

Let's talk.

Fill out the form below or email directly.

Or email: phoebegarcia@protonmail.com